Calcium-dependent Conformational Changes in Inositol Trisphosphate Receptors
نویسندگان
چکیده
منابع مشابه
Calcium-dependent clustering of inositol 1,4,5-trisphosphate receptors.
Rat basophilic leukemia (RBL-2H3) cells predominantly express the type II receptor for inositol 1,4,5-trisphosphate (InsP3), which operates as an InsP3-gated calcium channel. In these cells, cross-linking the high-affinity immunoglobulin E receptor (FcepsilonR1) leads to activation of phospholipase C gamma isoforms via tyrosine kinase- and phosphatidylinositol 3-kinase-dependent pathways, relea...
متن کاملTwo-state conformational changes in inositol 1,4,5-trisphosphate receptor regulated by calcium.
Inositol 1,4,5-trisphosphate receptor (IP3R) is a highly controlled calcium (Ca2+) channel gated by inositol 1,4,5-trisphosphate (IP3). Multiple regulators modulate IP3-triggered pore opening by binding to discrete allosteric sites within IP3R. Accordingly we have postulated that these regulators structurally control ligand gating behavior; however, no structural evidence has been available. He...
متن کاملActivating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate.
C calcium (Ca2 ) is a focal point of many signal transduction pathways and modulates a diverse array of cellular activities ranging from fertilization to cell death (1). Cells generate Ca2 signals through both internal and external Ca2 sources. In most cell types, the major internal Ca2 stores are the endoplasmic reticulum sarcoplasmic reticulum (ER SR). One mechanism for mobilizing such stores...
متن کاملTRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry.
C calcium serves as a ubiquitous signal for acute cellular activation and for regulation of important cellular processes such as cell growth, division, differentiation, and even cell death and apoptosis. Increases in cytoplasmic calcium or calcium signals can be generated either by release of calcium from intracellular stores or by influx of calcium across the plasma membrane, but commonly by b...
متن کاملThe inositol 1,4,5-trisphosphate receptors.
The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals. A single InsP3R isoform is expressed in Drosophila melanogaster (DmInsP3R) and Caenorhabditis elegans (CeInsP3R). ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.123208